REJEON PCL Yuzuza Injection Kurwanya-inkari guterura no gucana
Inkomoko ya REJEON PCL
Mu myaka 20 ishize, imyumvire yacu kuri kimwe mubice bigoye byumubiri wumuntu - isura - yateye imbere cyane, hamwe nuburyo bushya bwa anatomique bumaze kumenyekana.
Muri icyo gihe, ubwinshi bwo kutabaga
inzira zabonetse zo kuvura
ibimenyetso byo gusaza no kugarura urubyiruko
isura yo mu maso. REJEON niyambere, kandi
kuri ubu yonyine, kolagen sti mulator ikozwe muri microsperes ya polycaprolactone, igira uruhare mukuzamura ubwiza bwayo bwiza. REJEON
'Imiterere yihariye isobanura ko ari icyifuzo cya oporisiyo yuburyo bworoshye-tissue progaramu.
Incamake
Ibigize REJ EO N,
7 0% y'amazi ya CMC- ishingiye
gelna3 0% PCL
ibihimbano,Kuri
ingaruka zuzuye
byatewe na CMC, bigakurikirwa no gukangura umubiri wa kolagen (neocollagenezi).
CMC isubizwa 2 kugeza 3
amezi nyuma yo guterwakandi isimburwa gahoro gahoro numurwayi wenyine
kolagen (yiganjemo ubwoko bwa I) ikangurwa na
Microspheres ya PCL. Microsperes ya PCL nayo ni bioresorbable.
REJEON ifite ibiranga byinshi bituma ihitamo neza nkuzuza dermal:
NGusohora microsperes ya polymer, mugihe cyukwezi kumwe, hamwe na scagold ya kolagen ifitanye isano irinda izindi ngaruka zitera13.
Type Ubwoko bwa kolagen burambye kurubuga rwatewe inshinge ahanini ni 'abakuze' collagen scafold yubwoko bwa kolagen I5
a) Kugabanuka kwubwoko bwa kolagen III bivuze ko ntakindi gitera imbaraga zo gutwika
Kwangirika kw'ibigize REJEON birangizwa na hydrolysis, hasigara amazi na dioxyde de carbone gusa
EcKubera ko ingano yanyuma mugace kavuwe iruta ubwinshi bwa Ellansé yatewe, nta gisabwa 'gukoraho'
a) Ingano yanyuma iruta ingano yatewe na 20-30% bitewe no gukora ubwoko bwa kolagen I fibres11
AvailabilityKuboneka kwa verisiyo ebyiri za REJEON hamwe nibikorwa bitandukanye bivuze ko uburebure bwingaruka zo kuvura bushobora guhuzwa nu murwayi
ibisabwa
a) Ibi bigerwaho muguhindura uburebure bwiminyururu ya PCL, bikemerera guhanura, kugenzurwa no guhinduka bioresorption
TechniqueUbuhanga bwo kuvura ni bumwe utitaye ku bicuruzwa bya REJEON byatoranijwe a) Kimwe:
● Imiterere ya Rheologiya
● Ubuhanga
● Syringe
● Urushinge / urumogi
REJEON PCL Ibigize bidasanzwe
REJEON PCL igizwe nibidasanzwe, byemewe
kuvanga:
● 7 0% carboxymethyl selulose (CMC) - itwara gel
● 3 0% polycaprolactone (PCL) microsperes (Ishusho 1 .4) 3, 4, 5
Microspheres ya PCL ifitemo
abahuje ibitsina muri CMC ishingiye kuri gel. PCL na CMC byombi bifite umwirondoro mwiza kandi ugaragara.
REJEON PCL ibikoresho fatizo biva muri Gemany
PCL MICROSPHERES
PCL ni polyester yubuvuzi idafite uburozi, bwa mbere ikomatanyirizwa muntangiriro ya 1930s4, nibyo
ishimishije gukoreshwa mubuzuza dermal kubera koroshya bioresorption; mubisanzwe hydrolysed muri karuboni ya dioxyde namazi mumubiri5.
Microsperes ya PCL ikoreshwa muri
RE JEON yagenewe gutanga
biocompatibilité nziza6. Bafite ubuso bunoze, a
Imiterere ya sherfike n'ubunini bwa
hafi 25-50 mm
PCL ifite umwirondoro mwiza wumutekano3 kandi yakoreshejwe murwego rwibinyabuzima imyaka irenga 70 kubisabwa bitandukanye, kuva kuri suture kugeza tissue hamwe no gusimbuza ingingo hakoreshejwe icapiro rya 3D (Ishusho 1.6) 4. Irakoreshwa kandi muri CE yaranzwe na Amerika ibiryo na
Ubuyobozi bw'ibiyobyabwenge (FDA) - ibicuruzwa byemewe.
UMUTUNGO WA CMC
CMC ni ibintu bisanzwe bikomoka kuri selile; ntabwo ihujwe, kandi ntabwo ari uburozi. Ibindi bintu byayo birimo (Ishusho 1.7) 4:
● Nibikoresho byemewe bya farumasi
Is Ni hygroscopique
Byashyizweho na FDA nkuko bisanzwe bizwi nkumutekano (GRAS)
● Resorption ibaho mumezi 2 - 3
Ibyiza byingenzi bya REJEON PCL Uzuza
REJEON PCL ifite microse idasanzwe kandi itunganye, ifite ingano yujuje ubuziranenge bwumutekano mpuzamahanga nubuso bworoshye bushobora gukomeza guteza imbere imikurire ya kolagen.
Gukangura kwa kolagen by REJEON: Ibimenyetso bya siyansi
REJEON yabaye
kwipimisha mu nyamaswa
icyitegererezo aho inkwavu zatewe
haba REJEON S.
(PCL-1) cyangwa REJEON M (PCL-2) gukora iperereza kuri neocollagenezi5.
Amezi icyenda nyuma yo guterwa PCL- 1,
neocollagenezi yari yarabaye kandi microsperes ya PCL ya PCL- 1 yari yarahinduwe rwose (Ishusho 1. 1 1) 5.
Hagati aho, hamwe na PCL- 2 ku mezi 9,
hari ibimenyetso byerekana ko hashyizweho
andika I hanyuma wandike III kolagen hafi
Microspheres ya PCL. Mugihe cyamezi 2 1 nyuma yo guterwa, microsperes ya PCL- 2 yari ikiri muri tissue yatewe inshinge5.
Mu bushakashatsi bw’icyitegererezo kuri RE JEO N mu bantu, abarwayi bariyandikishije kugira ngo bakire Ellansé yatewe imbere mu rusengero
karere9. Isesengura ryamateka ya tissue yabonetse muri biopsies yagaragaye
kwibumbira hamwe kwa kolagen hafi ya PCL yatewe (Ishusho 1. 12) 9, ishyigikira ibisubizo bisa mbere byerekanwe muri
urukwavu.
REJEON uburyo bwibikorwa
REJEON ifite ibyiciro bibiri bitandukanye byibikorwa (Ishusho 1.9) 1,4:
● Intambwe ya 1: Ako kanya nyuma yo guterwa, igice cya CMC gitanga ingano yigihe gito,
bigenda bigabanuka buhoro buhoro mumezi 2-3
● Intambwe ya 2: Microspheres ya PCL itera
neocollagenezi yubwoko bwa I na III kolagen, hamwe nubwoko butajegajega I kolagen
imiterere yiyongera buhoro buhoro mumezi 1 - 3 na microsperes ya PCL
guhinduka muburyo bwa I kolagen
scafold. Ingano ya kolagen
gusimbuza ubwambere ubwiyongere bwatewe na CMC gel
Igikoresho cya kolagen cyatewe na PCL
microsperes ikomeza nyuma yo gusubizwa, biganisha ku kwiyongera kuramba kugaragara hamwe na REJEON
REJEON PCL Uzuza afite ibisubizo byiza
REJEON PCL Wuzuza ni murwego rwohejuru-rurerure rwuzuza ibintu rushobora koroshya ibimenyetso byasizwe nigihe kandi bigasubirana isura nubusore mumaso.
REJEON PCL YUZUYE CUSTOMER YUBUNTU
Turashaka gusangira ubuhanga bwacu kandi
ubumenyi mugihe nuburyo bwo kwinjiza r ej eon mubikorwa byubuvuzi. Nizere ko bizagirira akamaro abasomyi nkuko byankoreye mumyaka 10 ishize: gutanga imiti itekanye nibisubizo byiza nibisubizo biramba. RE JEON nigikoresho cyibanze mubikorwa byanjye kandi cyangize inshinge nziza! ”
Dr Francisco de Melo
Umuganga ubaga plastique, UAE
"RE JEON yabaye umukunzi wa dermal nkunda cyane
Imyaka 7. Iki gitabo kizagufasha kumenya ikoreshwa rya
RE JEON uzabikunda. ”
Dr Shang- Li Lin
Dermatologue, Tayiwani
“Gutezimbere mu miterere no ku ruhu
ubuziranenge buturuka kuri RE JOE N idasanzwe
neocollagenezi ntagereranywa. Nta gushidikanya, kimwe mu bikoresho byiza by’amavuriro bifuza gukora neza n’umutekano mu bicuruzwa byatewe. REJ EO N ifite
ubushobozi bwo gutanga igihe kirekire cyo guterura no kuzamura isura yo mumaso hamwe numwanya umwe gusa. ”
Dr Ingrid Ló pez- Gehrke
Dermatologue, Mexico
Ati: "Nishimiye cyane gukoresha RE JEON kubera ingaruka zidasanzwe za um umi kuririmba. Ibi biremera bike
ibicuruzwa bigomba gukoreshwa, kandi binyuze mubikorwa nyabyo bya kolagen ubwoko bwa I, bifite ubushobozi bwukuri kuruhu
kuvugurura. Abarwayi benshi barambwira bati: 'Ni ubwa mbere
Mfite ikintu kimara ', cyangwa' Reba ubwiza bwuruhu rwanjye '. Rwose nkunda kuzuza. ”
Dr Pierre Nicolau
Umuganga ubaga plastique, Espanye
REJEON MAJOR MILESTONES
Gukurikira ubushakashatsi niterambere ryinshi, nubuvuzi
kwipimisha, REJEON yabonye ISO 13485 Icyemezo cya sisitemu yo gucunga neza muri
20081 (Igicapo 1.2). Muri 2009, kwemeza ibimenyetso by’iburayi (CE) byari
yahawe, kuyobora
Kuri Gutangiza cyane
ibicuruzwa mu Bwongereza, Ubudage na Espanye. Ibindi byoherejwe byakurikiranye, byanditswe muri barenga 69
ibihugu bitarenze 2018. Muri 2019 ,.
Isabukuru yimyaka 10 ya rejeon, nibindi
siringi zirenga miliyoni
kwisi yose. Ariko inkuru yo gutsinda ntiyagarukiye aho, hamwe nurubuga rushya rwo gukora mubuholandi
umusaruro muri 2020
REJEON PCL PRODUCT Ibisobanuro birambuye
1ml / igice
Emera OEM yihariye
